To meet our 2027 goals, we need to be held accountable for everything we do, from monitoring energy consumption to promoting best practices with our teams. Where we want to be: An additional 75% less waste generated by 2027. 0000010380 00000 n Amgen has created a number of websites to better serve you with specific questions. We may use it to: To learn more about how we handle and protect your data, visit our privacy center. The adjustments relate primarily to noncash amortization of intangible assets acquired in business acquisitions. A Phase 3 trial continues to enroll using this combination. Amgenreleased its2021 Environmental, Social & Governance (ESG) report, providing a comprehensive overview of the many ways the Company is doing its part to build a better, healthier world. Key results include: For the fourth quarter, total revenues increased 3% to $6.8 billion in comparison to the fourth quarter of 2020, driven by increased Other Revenue from the Generally, this results in a tax impact at the U.S. marginal tax rate for certain adjustments, including the majority of amortization of intangible assets, whereas the tax impact of other adjustments, including restructuring initiatives, depends on whether the amounts are deductible in the respective tax jurisdictions and the applicable tax rate(s) in those jurisdictions. We also strive to be a responsible corporate citizen and good neighbor. Management has also presented Total Revenues Adjusted for Foreign Currency Impact, which is a non-GAAP financial measure, for the third quarter of 2022. Known adjustments to arrive at non-GAAP*: * The known adjustments are presented net of their related tax impact, which amount to approximately $1.29 - $1.30 per share. Beginning January 1, 2022, following industry guidance from the U.S. Securities and Exchange Commission, the Company no longer excludes adjustments for upfront license fees, development milestones and IPR&D expenses of pre-approval programs related to licensing, collaboration and asset acquisition transactions from its non-GAAP financial measures. in a mostly pretreated advanced non-small cell lung cancer (NSCLC) population, lead-in cohorts treated with LUMAKRAS followed by a combination of LUMAKRAS and immunotherapy demonstrated durable clinical activity with lower rates of grade 3-4 Treatment-Related Adverse Events (TRAEs) compared to concurrently treated cohorts. We never underestimate the power of strong supplier relationships, and we strive to work with suppliers who hold the same values as us. Foreign currency impact was calculated by converting our current period local currency Product sales using the prior period foreign currency exchange rates and comparing that to our current period Product sales. The discovery of significant problems with a product similar to one of our products that implicate an entire class of products could have a material adverse effect on sales of the affected products and on our business and results of operations. Provide specific products and services to you, such as portfolio management or data aggregation. A spokesperson told this reporter that the company was not yet ready to discuss our sustainability efforts around our packaging, but did offer a fact sheet about the broader sustainability efforts of the Thousand Oaks, CA-based human therapeutics firm. For the full year 2022, the Company now expects: Third Quarter Product and Pipeline Update. Report Locked. 2021 Environmental, Social & Governance Report, 2020 Environmental, Social & Governance Report, View Environmental, Social & Governance Report. How we use your information depends on the product and service that you use and your relationship with us. 0000002369 00000 n 0000002406 00000 n The High Meadows Institute (HMI), a think tank and policy institute focused on strengthening the role of business leadership in creating a sustainable society, is a Strategic Partner. THOUSAND OAKS, Calif., Nov. 3, 2022 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today announced financial results for the third quarter of 2022. Beginning January 1, 2022, the Company's non-GAAP financial measures no longer exclude adjustments for upfront license fees, development milestones and IPR&D expenses of pre-approval programs related to licensing, collaboration and asset acquisition transactions. Consolidated Statements of Income - GAAP THOUSAND OAKS, Calif., May 2, 2022 /PRNewswire/ -- Amgen (NASDAQ:AMGN) today released its 2021 Environmental, Social & Governance (ESG) report, providing a comprehensive overview of the many ways the Company is doing its part to build a better, healthier world. Adjustments to selling, general and administrative expenses: Total adjustments to selling, general and administrative expenses, Non-GAAP selling, general and administrative expenses, GAAP selling, general and administrative expenses as a percentage of product sales, Non-GAAP selling, general and administrative expenses as a percentage of product sales, Adjustments to research and development expenses, Adjustments to selling, general and administrative expenses, Certain charges pursuant to our cost savings initiatives, GAAP operating income as a percentage of product sales, Non-GAAP operating income as a percentage of product sales. 0000006036 00000 n We use a stringent performance reporting system to ensure these sustainable values and initiatives permeate every one of our divisions throughout the world. 0000022272 00000 n We work toward a more just society for our employees and the people we serve. We prioritize sustainability and aim to minimize our environmental impact to preserve natural resources for generations to come. We hold ourselves to high standards in our operations, working to ensure our actions and culture reflect Amgen's values. We also ensure all medicines are regulated by the European Medicines Agency, and comply with standards set by the: We regularly conduct staff engagement surveys and run round-table discussions to promote a sustainability-first culture, recording our teams thoughts on our progress so far. LETTER FROM BOB DeLLpro-300, a Phase 1b study of tarlatamab, continues to enroll patients with de novo or treatment-emergent neuroendocrine prostate cancer. As a science-based company with a mission to serve patients, we understand the profound impact that climate change is having on human health around the world. 0000084893 00000 n The fact sheet says, As a global leader in human therapeutics, Amgen is committed to environmentally responsible operations, using natural resources wisely, and considering its overall impact on the environment.. An abstract based on the end-of-treatment analysis data from a Phase 2 study of olpasiran, a small interfering RNA molecule that reduces Lipoprotein(a) (Lp(a)) synthesis in the liver in subjects with elevated Lp(a) has been accepted as a late-breaking clinical trial presentation at AHA in November. Dose expansion is ongoing in treatment-nave patients using lower-dose LUMAKRAS lead-in followed by combination of LUMAKRAS with pembrolizumab. Rocatinlimab, formerly AMG 451 / KHK4083 is being developed in collaboration with KKC. (In millions) Amgen's 2027 Environmental Sustainability Plan, also known as The Road to Net Zero, features ambitious targets on carbon emissions, water conservation and waste reductions. Otezla treatment showed a clinically meaningful and statistically significant improvement in genital psoriasis, including improvements in skin clearance, itch, and quality of life at week 16 compared with placebo. Amgen Inc. For purposes of comparability, the non-GAAP financial results for the third quarter of 2021 have been updated to reflect this change. 0000078392 00000 n Amgen focuses on areas of high unmet medical need and leverages its expertise to strive for solutions that improve health outcomes and dramatically improve people's lives. Dow showcased its REVOLOOP portfolio at PACK EXPO International. Adjustments to the most directly comparable GAAP financial measures and other items are presented on the attached reconciliations. By continuing to report on our operations throughout Europe and beyond, we can move forward and achieve these targets. Discovery or identification of new product candidates or development of new indications for existing products cannot be guaranteed and movement from concept to product is uncertain; consequently, there can be no guarantee that any particular product candidate or development of a new indication for an existing product will be successful and become a commercial product. We may not be able to access the capital and credit markets on terms that are favorable to us, or at all. Increasing the percentage of women in manager and above roles, Increasing the percentage of women in senior vice president and above roles, which is also defined as our operating team, Increasing the percentage of African Americans in science titles, Increasing the percentage of African Americans and Hispanics in executive director and above roles. Ordesekimab formerly AMG 714 and also known as PRV-015 is being developed in collaboration with Provention Bio. Apply today at CareerBuilder! We report all progress in line with the Carbon Disclosure Project. Drive program implementation necessary to provide transparent reporting to meet external partner expectations to promote a positive company image. 0000047523 00000 n These non-GAAP financial measures are computed by excluding certain items related to acquisitions, divestitures, restructuring and certain other items from the related GAAP financial measures. We are working to help build a Our business and operations may be negatively affected by the failure, or perceived failure, of achieving our environmental, social and governance objectives. FORTITUDE-102, a Phase 1b/3 study of bemarituzumab plus chemotherapy and nivolumab versus chemotherapy and nivolumab in first-line gastric cancer with FGFR2b overexpression is enrolling patients in the Phase 3 portion of the study. Amgen has invested $200 million (170 million) globally into environmental sustainability projects, with the latest seven-year plan released on January 11, 2021. Amgen Inc. (ilgari A pplied M olecular Gen etics Inc.) Amerikaning kop millatli biofarmatsevtika kompaniyasi bolib, shtab-kvartirasi Kaliforniya shtati, Thousand Oaks shahrida joylashgan . we use to gather and assess environmental data from Amgens major manufacturing, research and development, and distribution facilities representing more than 90 percent of Amgens Updated Amgen's sustainability design standard target for the LEED CERTIFICATION (Leadership in Energy and Environmental Design), the most widely used green building rating system globally, from Silver to Gold. Adjustments to other income (expense), net: Equity method investment basis difference amortization, Net (gains)/losses from equity investments, Total adjustments to other income (expense), net. This is Amgens third environmental sustainability plan since 2007, and we have seen myriad success stories in our European operations. "This growth reflects the strong underlying demand for our medicines and the value they bring to patients.". This approach begins by using tools like advanced human genetics to unravel the complexities of disease and understand the fundamentals of human biology. 0000005386 00000 n 2021 ESG News Corp. All rights reserved. Transparency is how we protect the integrity of our work and keep empowering investors to achieve their goals and dreams. Planning is underway for a Phase 3 study in patients with eosinophilic esophagitis. We also sell both admissions and sponsorship packages for our investment conferences and advertising on our websites and newsletters. The adjustment primarily relates to a cumulative foreign currency translation adjustment from a nonstrategic divestiture. This prompted analysts from Wolfe Research to strike a note of caution. Added an ESG goal to the Companys goals for our annual incentive plans to focus our entire Company on activities supporting achievement of our 2027 environmental sustainability targets and to strengthen and improve the Companys diversity, inclusion, and belonging efforts. To further our progress, Amgen has included an ESG goal again for 2022. We sell different types of products and services to both investment professionals and individual investors. Otezla treatment resulted in significant improvements in measures of disease severity at week 16 compared with placebo. For purposes of comparability, the non-GAAP financial results for the third quarter of 2021 have been updated to reflect this change. We perform a substantial amount of our commercial manufacturing activities at a few key facilities, including in Puerto Rico, and also depend on third parties for a portion of our manufacturing activities, and limits on supply may constrain sales of certain of our current products and product candidate development. Amgen released its 2021 Environmental, Social & Governance (ESG) report, providing a comprehensive overview of the many ways the Company is doing its part to build a Regulatory reviews continue in other jurisdictions. Forward-looking statements involve significant risks and uncertainties, including those discussed below and more fully described in the Securities and Exchange Commission reports filed by Amgen, including our most recent annual report on Form 10-K and any subsequent periodic reports on Form 10-Q and current reports on Form 8-K. Our business performance could affect or limit the ability of our Board of Directors to declare a dividend or our ability to pay a dividend or repurchase our common stock. we use to gather and assess environmental data from Amgens major manufacturing, research and development, and distribution facilities representing more than 90 percent of Amgens operations . Our stock price is volatile and may be affected by a number of events. Report this post Our commitment to have a healthier planet is embedded in everything we do. This in turn follows the recommendations from the Taskforce on Climate-Related Financial Disclosures. In August, Phase 1 data from DeLLphi-300 were presented demonstrating that in heavily pretreated patients with small-cell lung cancer (SCLC), tarlatamab, a half-life extended (HLE) bispecific T-cell engager (BiTE. No forward-looking statement can be guaranteed and actual results may differ materially from those we project. For the nine months ended September 30, 2022, the adjustments related primarily to cumulative foreign currency translation adjustments from a nonstrategic divestiture. All statements, other than statements of historical fact, are statements that could be deemed forward-looking statements, including any statements on the outcome, benefits and synergies of collaborations, or potential collaborations, with any other company (including BeiGene, Ltd., Kyowa-Kirin Co., Ltd., Generate Biomedicines, Inc., Arrakis Therapeutics, Inc., Plexium, Inc., or any collaboration to manufacture therapeutic antibodies against COVID-19), the performance of Otezla (apremilast) (including anticipated Otezla sales growth and the timing of non-GAAP EPS accretion), the Five Prime Therapeutics, Inc. acquisition, the Teneobio, Inc. acquisition, or the ChemoCentryx, Inc. acquisition as well as estimates of revenues, operating margins, capital expenditures, cash, other financial metrics, expected legal, arbitration, political, regulatory or clinical results or practices, customer and prescriber patterns or practices, reimbursement activities and outcomes, effects of pandemics or other widespread health problems such as the ongoing COVID-19 pandemic on our business, outcomes, progress, and other such estimates and results. 0000005952 00000 n This all starts with a sustainable value chain. from a Phase 2 study of rocatinlimab, an anti-OX40 monoclonal antibody, which demonstrated improvement in head and neck atopic dermatitis in patients with moderate to severe disease. We or others could identify safety, side effects or manufacturing problems with our products, including our devices, after they are on the market. A Phase 2 study continues to enroll patients with chronic obstructive pulmonary disease.
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