This site uses cookies to give you the best online experience. October 4, 2022 -- Voyager Therapeutics, Inc. (Nasdaq: VYGR), a gene therapy and neuroscience company developing life-changing treatments and next-generation adeno-associated virus (AAV) capsids, today announced that Pfizer, Inc. (NYSE: PFE) has exercised its option to license a novel capsid generated from Voyagers TRACERTM capsid Minister of Innovation, Science and Industry Report a problem on this page. Over the course of his nearly 10-year tenure there, he developed and launched global tools to support Novartis from early discovery work through to clinical trials. Two of the targets directly focus on preventing and controlling CVDs. GlobalBloodTherapeutics,Inc. In connection with the acquisition, GBTs shares of common stock ceased trading on the NASDAQ Global Select Market. As a global company that places high value on collaborative interactions, rapid delivery of solutions, and providing the highest level of quality, we strive to meet this challenge. An unblinded trial in 219 children and adults with type 1 diabetes found that a fully automated system of insulin delivery led to greater reduction in hemoglobin A1C and more time spent in the target glucose range without increasing hypoglycemia. Find the latest stock market trends and activity today. Hyperglycaemia, also called raised blood glucose or raised blood sugar, is a common effect of uncontrolled diabetes and over time leads to serious damage to many of the body's systems, especially the nerves and blood vessels. Most cardiovascular diseases can be prevented by addressing behavioural risk factors such as tobacco use, unhealthy diet and obesity, physical inactivity and harmful use of alcohol. Hyperglycaemia, also called raised blood glucose or raised blood sugar, is a common effect of uncontrolled diabetes and over time leads to serious damage to many of the body's systems, especially the nerves and blood vessels. Cancer has a major impact on society in the United States and across the world. They are a constellation of multiple genetically and biologically distinct diseases that affect patients differently. They follow a rigorous editorial process and align with our Lexicomp editors to provide holistic decision support. The information contained in this release is as of October 5, 2022. Women are more likely than men to have shortness of breath, nausea, vomiting, and With Global Blood Therapeutics talent, portfolio, and pipeline now part of Pfizer, we look forward to accelerating innovation and expeditiously bringing multiple potential best-in-class treatments to people living with sickle cell disease, said Aamir Malik, Chief Business Innovation Officer, Executive Vice President, Pfizer. Proposed acquisition drives growth by bringing leading sickle cell disease expertise, portfolio and pipeline to Pfizer with potential combined worldwide peak sales of more than $3 billion Potential to address the full spectrum of critical needs in the underserved sickle cell community Transaction valued at $68.50 per Global Blood Therapeutics share in cash, for Partnering for perfection: How lenders can stay ahead, LegalVIEW Insights: Finance companies spend is high but flat, CPM trend breakdown: new challenges and complexity in performance management, What to watch out for when you self-file UCCs, What to look for in a corporate service provider, Best practices for selecting a post-merger integration team, Using an Authoritative Source Library (ASL) to connect regulatory change to your compliance program, Companies buying companies: The different types and methods of mergers and acquisitions, Business license pitfalls for architecture and engineering companies, Follow the four Vs to achieve artificial intelligence maturity, Checklist: Set yourself up for success in 2023 and beyond, Lien and risk management for financial professionals, Congratulations to our 2022 Legal Innovators, How to obtain a Federal EIN: Information for corporations and law firms. All content is available on the global site. The significance of the discovery of RNAi was recognized with the 2006 Nobel Prize in Medicine or Physiology. CAMBRIDGE, Mass. Acquisition brings leading sickle cell disease portfolio and pipeline to Pfizer with potential to address critical needs in an underserved patient community Pfizer Inc. (NYSE: PFE) announced today the completion of its acquisition of Global Blood Therapeutics, Inc. (GBT), a biopharmaceutical company dedicated to the discovery, development and delivery of life Driven by leading physicians and pharmacists. Rheumatic fever mostly affects children in developing countries, especially where poverty is widespread. Before taking Oxbryta, patients should tell their healthcare provider about all medical conditions, including if they have liver problems; if they are pregnant or plan to become pregnant as it is not known if Oxbryta can harm an unborn baby; or if they are breastfeeding or plan to breastfeed as it is not known if Oxbryta can pass into breastmilk or if it can harm a baby. In addition, drug treatment of hypertension, diabetes and high blood lipids are necessary to reduce cardiovascular risk and prevent heart attacks and strokes among people with these conditions. GBT is now part of Pfizer! It istesting whether inclacumab taken every 12 weeks can reduce the risk of VOCs relative to a placebo. Evidence from 18 countries has shown that hypertension programmes can be implemented efficiently and cost-effectively at the primary care level which will ultimately result in reduced coronary heart disease and stroke. BAGSVRD, Denmark & WATERTOWN, Mass.--(BUSINESS WIRE)--Sep. 1, 2022-- Novo Nordisk and Forma Therapeutics, Holdings Inc. (Nasdaq: FMTX) today announced that they have entered into a definitive agreement under which Novo Nordisk will acquire Forma Therapeutics for $20 per share in cash, which represents a total equity value of $1.1 billion. All rights reserved. Target 6: Reduce global prevalence of raised blood pressure by 25% between 2010 and 2025. The NRC's Human Health Therapeutics Research Centre receives funding for pediatric cancer research. UK Biobank Exome Sequencing Consortium (UKB-ESC), Ability to target potentially any gene in the genome, including targets that are undruggable by small molecules and antibodies, Highly potent and durable effect (dosing as infrequently as biannual or annual), Administration through multiple routesintravenous (IV), subcutaneous, and inhalation delivery, Demonstrated clinical benefit with a lower dose and dose frequency, and an encouraging overall safety profile compared to other approaches to gene silencing, Modular, reproducible, and consistent performance across organs and diseases. This release contains forward-looking information about, among other things, Pfizers acquisition of GBT, Oxbryta, GBTs pipeline, including inclacumab and GBT021601 (GBT601), and potential peak sales, and expected best-in-class and growth potential, including their potential benefits, that involve substantial risks and uncertainties that could cause actual results to differ materially from those expressed or implied by such statements. View source version on businesswire.com: https://www.businesswire.com/news/home/20221004006158/en/, Media:[emailprotected] Pfizer will continue to build on the companies shared commitment to and engagement with the SCD community. You also have the option to opt-out of these cookies. This site is strictly a news and information website about the disease. He holds an A.B. Insulin is a hormone that regulates blood glucose. Offers modern, cloud-based employee benefits and pension software, UpToDate: Industry-leading clinical decision support. Wolters Kluwer supports public health needs in resource-limited settings with complimentary UpToDate access. We challenge assumptions and dont accept the status quo. Compare key indexes, including Nasdaq Composite, Nasdaq-100, Dow Jones Industrial & more. He leads a multi-disciplinary data science team and informatics team to support the companys goal to transform genetic and real-world data discoveries into testable hypotheses related to the treatment of common, complex diseases. In that role, he led key neuroscience programs delivering clinical candidates for Alzheimers disease (AD) and multiple sclerosis (MS). Vaccines, like those developed for COVID-19 and influenza, are developed to stimulate the immune system to produce antibodies that would result from exposure to a particular disease. Patients should not breastfeed during treatment with Oxbryta and for at least 2 weeks after the last dose. We routinely post information that may be important to investors on our website at www.Pfizer.com. He focuses on life science. California COVID Notify Pilot Program. When you face a challenging clinical question or need to confirm your approach, you can turn to UpToDate for trusted answers based on the latest evidence and best practice. In recognition of the critical need for new SCD treatments, the FDA granted Oxbryta Breakthrough Therapy, Fast Track, Orphan Drug, and Rare Pediatric Disease designations for the treatment of patients with SCD. Shes won a Society of Professional Journalists award for outstanding reporting. Out of the 17 million premature deaths (under the age of 70) due to noncommunicable diseases in 2019, 38% were caused by CVDs. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Copyright 2022 Alnylam Pharmaceuticals, Inc. All Rights Reserved, LEVERAGING GENETICS TO ACCELERATE DRUG DEVELOPMENT. Of the 120 million people around the world thought to have SCD, more than 66% live in Africa. Patients should tell their healthcare provider or get emergency medical help right away if they get rash, hives, shortness of breath (difficult breathing) or swelling of the face. stress and hereditary factors. RNAi therapeutics is an innovative new class of medicines based on RNA interference (RNAi)a breakthrough discovery in understanding how genes are regulated naturally within cells. How siRNAs Work. CA COVID Notify uses the Exposure Notifications System from Google and Apple to quickly notify you if youve likely been exposed to COVID-19, allowing you to seek medical attention and reduce risk for your friends, family and the UC San Diego community. 25th Global Obesity Meeting, Rome, Italy: April 17-18, 2023 16th international conference on Transplantation and Medical Surgery, Rome, Italy: April 19-20, 2023 8th International Conference on Pediatrics and Pediatric Surgery, Rome, Italy: April 19-20, 2023 24th Global Nephrology, Urology and Kidney Failure Congress, Rome, Italy: April 24-25, 2023 Significance of the 120 million people around the world States and across the world seek the of!, he led key neuroscience programs delivering clinical candidates for Alzheimers disease ( AD ) multiple. Inclacumab taken every 12 weeks can reduce the risk of VOCs relative to a placebo process and with. 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