It is administered through a shot twice per year for up to 10 years. Check with your doctor or nurse immediately if any of the following side effects occur while taking zoledronic acid: Some side effects of zoledronic acid may occur that usually do not need medical attention. Im done! As I was reluctant, we agreed to give it a 2 year trial and see if it helps to give me a kick start, then see about not taking it. They are not swollen at all but the pain is unbearable. yaelsmith 4 years ago. Was it really PD? We comply with the HONcode standard for trustworthy health information. Does anyone know how long this lasts? I have been on Prolia for 3-1/2 years. chemotherapy, radiotherapy, corticosteroids) and co-morbid conditions (e.g. How long do the side effects of Prolia last? O 0, 5. Itching to death and still have very bad skin condition. I only had two injections. I called his nurse and told her that I WOULD NOT be taking Fosamax! Australian prescription products guide online. Many of these patients had signs of local infection including osteomyelitis, and the majority of the reports refer to cancer patients following tooth extractions or other dental surgeries. Hypercalcaemia (elevated calcium (ca+) level in the blood): 219 reports. Perhaps a person who does not suffer from Fibro, or osteoarthritis, or similar disorders may have a different outcome taking Prolia, but from what I have seen with my sister's reaction to this drug I would strongly caution anyone who suffers from similar ailments, especially Fibro, to stay clear of Prolia. Because the drug can stay in your body for up to 6 months, some side effects can still occur months after your last dose of Prolia. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. I immediately called my oncologist and told them the ER doctor had connected the dots to Prolia. I do not get severe reactions, but for the first few months of the second Shot especially, I was very achy, knees, thighs, elbows and back. All she said to me was you have osteoporosis and the doctor wants you to take fosamax! The study is based on denosumab (the active ingredients of Prolia) and Prolia (the brand name). When denosumab injection (Prolia) is used for osteoporosis or bone loss, after you receive the missed dose, your next injection should be scheduled 6 months from the date of your last injection. How long will the side effects of Prolia last? Ff to March 2018. I don't know if it builds up in the body or what is going on. Prolia can also cause serious skin infections like cellulitis and other serious infections like endocarditis . Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. I think Im going to call my doctor and ask that same question! I also experience tingling in the tips of mostly my right fingers and right elbow, but sometimes my left fingertips tingle, too. Available for Android and iOS devices. You may be able to better handle this drug as compared to the prolia. The reason I am having so many questions/concerns, and anger about Prolia and Fosamax is because of the answers or denials about how both of these would affect they would have on my Major Depressive Disorder and the meds I take for it as well as how they would affect my Macular Degeneration and the meds I take for it, and finally how they would affect my seizure disorder and the meds it take for it. Some reports may have incomplete information. Prolia - Why don't doctors apprise patients about side effects. How are you feeling now? My bone density showed a small improvement in the spine, but more bone loss in the hip. Kathy I took this damn drug for 5 months, stopped in early March, 2019still having severe leg pain and weakness, spasms, lower back paincannot do things I used to do. Pain in the arms or legs. I had no cavities in 5 years. They all sad it was fine with all my medications for Major Depressive Disorder, anxiety, seizure disorder, macular degeneration. Is prolia given intravenously? Since stopping that is fine. My last injection was April 2018. I will not be getting anymore! It took a year post med. I also saw my physical therapist. I had my second shot 31 days ago. They then had between them some 50 vertebral fractures in short order that the paper blamed on a rebound effect from the drug. It works by turning off the natural process of breaking down and reabsorbing bones. Of course the dr said no other patient has had any symptons. Copyright 2022 IBM Watson Health. Check with your doctor or nurse immediately if any of the following side effects occur: Some side effects may occur that usually do not need medical attention. To learn more about Prolia's side effects, talk with your doctor or pharmacist. http://www.appco.com.au/appguide/default.asp" (2006): 4. Amgen lists a number of horrifying adverse effects of Prolia. Out of the 50,000 the FDA ran the test on, 182 had cavities - which is nothing they say. I am very itchy and scratch and get spotty rashes. Other times, it is just a constant hurt, but it hurts all the time. anemia, coagulopathies, infection, pre-existing oral disease). Some dosage forms listed on this page may not apply to the brand name Reclast. She took Fosamax for years for bone density issues and osteoporosis, but recently a new Dr decided she needed to switch and suggested Prolia. Kidney Int 64 (2003): 281-289. This last injection, I ended up in ER with severe ear pain, swollen face, eyes swollen shut and fast heart rate, along with UTI two days later. Your doctor seems to be misinformed. I just got my first Prolia shot yesterday and I have no pain, I am hoping it will not happen. Community Discussion: "I got my shot in my left arm and I have had stronger issues with my left side. I am about 80% back to myself. I went to my doc and he ran tests and gave me steroids for a week to calm the inflammation. I dont know how I got it. I had to visit numerous Dr's to solve the skin problem (cortisone ) three skin biopsies. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. [Ref], Very common (10% or more): Hypotension (10.5%), Uncommon (0.1% to 1%): Palpitations, flushing, hypotension, hypotension leading to syncope or circulatory collapse, Very rare (less than 0.01%): Cardiac arrhythmia (secondary to hypocalcemia), Postmarketing reports: Atrial fibrillation, hypertension, bradycardia, and hypotension[Ref], In the postmenopausal osteoporosis trial, adjudicated serious adverse events of atrial fibrillation in the zoledronic acid treatment group occurred in 1.3% of patients (50 out of 3862) compared to 0.4% (17 out of 3852) in the placebo group. Best wishes for you to feel better. My hair started to grow back and my nails are normal now. God only knows how long I (we) will live with this. I tried talking to all my doctors, but none of them would tell me the truth about anything. I never had skin problem. I had to stop the drug. I was going crazy! Never talked to me about anything. I did not take my 4th shot which was about 4 months ago but I am still itchy. I'm so sorry you are feeling this bad. I am 63 and feel 83. So tired and I require so much rest and sleep all night. FDA Urges Caution Over Long-Term Use of Bone-Density . If we combine this information with your protected Anyone tried Prolia for osteoporosis? The worst was I experienced angioedema of the face. The overall incidence of all atrial fibrillation adverse events in the zoledronic acid treatment group was, reported in 2.5% of patients (96 out of 3862) in the Reclast group vs. 1.9% of patients (75 out of 3852) in the placebo group. Right?Well,,, they were not just talking.They had agents stand in the pharmacy lines to count how many times the question was not asked. Any question I would ask On Line would twist it around and say that all of these medications and/or the issues I have were the causes of osteoporosis! Sometimes I feel a burning sensation from my right shoulder all the way down to my right pinkie.I have had 5 rib fractures since starting Prolia. Mayo Clinic on Incontinence - Mayo Clinic Press, NEW The Essential Diabetes Book - Mayo Clinic Press, NEW Mayo Clinic on Hearing and Balance - Mayo Clinic Press, FREE Mayo Clinic Diet Assessment - Mayo Clinic Press, Mayo Clinic Health Letter - FREE book - Mayo Clinic Press. I keep hoping it's going to go away but it hasn't. I am meeting with my doctor next week, as I told him I refuse to take any more Prolia injections; however, I have read about the possible complications of discontinuing it, and it really scares me -- but not enough to continue with it.On some mornings, the weakness and pain in my right arm is so severe that it hurts to raise my arm to blow my hair dry or brush my teeth.I really am not one to complain, and I can put up with a lot if I know it will benefit me. This drug has almost completely destroyed my sister's well being both mentally and physically. generic drugs) are not considered. Inability to concentrate due to pain. My endocrinologist told me there is a rebound effect and one has to transition to another medication for 6 months to deal with this. So now I am afraid to try anything else. Prolia stays in your body for over 4 months so some of these side effects can last a long time, Adachi from Osteoporosis Canada, according to Dr Even the commen scared the crap out of Me! The best advise I can give to everyone, change your eating habits and excercise, especially the weight bearing ones, walk everyday and stay happy WITHOUT PROLIA.Good luck everyone. All rights reserved. I haven't had a fracture since I started this drug which in itself is a miracle. After the first 12, they did another DEXA scan, & I had all kinds of new bone bulding. . Now, we have got a complete detailed explanation and answer for everyone, who is interested! If this commentary about my sister's situation helps anyone from going through what my sister has endured then I feel I have done a service to those about to embark on taking this drug. How long do the side effects last???? I have another bone density in February and see if the bones are any better. I wish I had never taken the first shot. My rash has never completely gone away.The medication might cause a antigen antibody reaction, which is why I had the rash and itching.Dr wanted me to try reclast, when I looked up the side effects I was not happy with patient reactions. Advertising revenue supports our not-for-profit mission. Went in for forth one I was saying no and he insisted that prolia was not causing my pain it was fibromyalgia. Prolia (131,809 reports) Common Prolia side effects: Abasia (inability to walk): 267 reports Abdominal discomfort: 709 reports Abdominal distension: 367 reports Abdominal pain: 814 reports Abdominal pain lower: 107 reports Abdominal pain upper: 781 reports Acne (skin problems that cause pimples): 159 reports He/she needs to know of the side effect and your unbearable pain.Good luck to you,Sweet Hippie. Anyone tried Prolia for osteoporosis? [Ref], Very common (10% or more): Alopecia (12%) and dermatitis (11%), Uncommon (0.1% to 1%): Pruritus, hyperhidrosis, rash (including erythematous and macular rash), increased sweating, Frequency not reported: Stevens-Johnson syndrome, epidermal necrolysis, Postmarketing reports: Increased sweating and urticaria[Ref], Very common (10% or more): Nausea (29.1% to 46%), vomiting (14% to 32%), constipation (26.7% to 31%), diarrhea (17.4% to 24%), abdominal pain (14% to 16.3%), dyspepsia (10%), Common (1% to 10%): Stomatitis, sore throat, dysphagia, Uncommon (0.1% to 1%): Gastroesophageal reflux disease, esophagitis, toothache, gastritis, Very common (10% or more): Urinary tract infection (14%)[Ref], Very common (10% or more): Anemia (22.1% to 33%) and neutropenia (12%), Common (1% to 10%): Granulocytopenia, thrombocytopenia and pancytopenia, Grade 3 and 4 laboratory abnormalities have included hypophosphatemia (51.4%, grade 3; 1.4%, grade 4) and hypocalcemia (1.2%, grade 3).[Ref]. The most common side effects of Prolia include: bladder infection, painful or difficult urination, back pain, muscle pain, and pain in your arms or legs Tell your doctor if you have any side effect that bothers you or that does not go away. [Ref], Cases of osteonecrosis (primarily of the jaws) have been reported, predominantly in cancer patients taking this drug. The frequency of renal impairment adverse events suspected to be related to this drug was as follows: Multiple myeloma (3.2%), prostate cancer (3.1%), breast cancer (4.3%), lung and other solid tumors (3.2%). So I dont know how long before I have any side effects, hopefully I will not or I will be devastated. Is this stuff accumlative? Results of our real-world drug study have been referenced on 600+ medical publications, including The Lancet, Mayo Clinic Proceedings, and Nature. One can only wonder what other side effects are there if the manufacturer admits to such profound damages. Hi Crazy & Hazel,First off I have not taken Prolia but Im a nurse and looked it up.Im amazed at what I found.Just curious, what did your doctor tell you about the pain, etc ?What was the advice given by him?If you want, we could discuss this drug.Let me know.Be well :-). She was told that probably after about six months the pain would maybe start to go away gradually, over several weeks to six months it would go away. To include hip pain, hip infection, bone pain and unable to stand because it hurt so bad. This time the pain would not quit. I had three but didnt have hand pain. I went to a pain management doctor who prescribed Garapentin which helped some.
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