Doptelet Side Effects & Interactions | RxSaver Store at room temperature away from moisture and heat. "Product Information. 1996-2022 RxList, Inc. All rights reserved. The most common side effects of DOPTELET when used to treat low blood platelet counts in adults with ITP are headache, tiredness, bruising, nosebleeds, upper-respiratory tract infection, joint pain, gum bleeding, purple or red spots on your skin, and a runny nose. Doptelet - Avatrombopag uses, dose and side effects - zeepedia.com The most common side effects of Doptelet in clinical trials include: Pyrexia; Abdominal pain, nausea; Headache, fatigue; Edema; Arthralgia - joint pain; In rare instances, Doptelet can cause more serious adverse effects. PDF Discover the Possibilities With Doptelet swelling, pain, or tenderness in your legs The racial and ethnic distribution was White (84%), Black (6%), Asian (6%) and Other (6%). Doptelet: Dosage, uses, side effects, and more These can include: Thrombotic - monitor platelet counts and for thromboembolic events DOPTELET may cause serious side effects such as blood clots. Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Doptelet: Dosing, contraindications, side effects, and pill pictures . Increase the recommended starting dosage of DOPTELET when used concomitantly with a moderate or strong dual inducer of CYP2C9 and CYP3A4 (see Table 4) [see DOSAGE AND ADMINISTRATION]. Copyright 2022 by RxList Inc. RxList does not provide medical advice, diagnosis or treatment. The safety of DOPTELET was evaluated in two international, identically designed, randomized, double-blind, placebo-controlled trials, ADAPT-1 and ADAPT-2, in which 430 patients with chronic liver disease and thrombocytopenia received either DOPTELET (n=274) or placebo (n=156) daily for 5 days prior to a scheduled procedure, and had 1 post-dose safety assessment. You could develop a blood clot while using avatrombopag. The most commonly reported side effects are fever, abdominal pain, nausea, headache, fatigue and swelling of the feet or. Your doctor will measure your platelet levels with a blood test before you start taking this medicine. Promacta Side Effects: Common, Severe, Long Term - Drugs.com This survey is being conducted by the WebMD marketing sciences department. Get emergency medical help if you have signs of an allergic reaction to Doptelet: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. Mulpleta vs Doptelet - What's the difference? CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. Before a scheduled medical procedure: Call your doctor for instructions if you miss a dose. Your healthcare provider may change your dose of DOPTELET depending on your blood platelet counts. Doptelet is also used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough. Other drugs that have the same active ingredients (e.g. pain in the chest, groin, or legs, especially the calves. Call your doctor or get emergency medical help if you have: The following clinically significant adverse reactions are discussed in detail in other sections of the labeling: Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. Read the entire FDA prescribing information for Doptelet (Avatrombopag Tablets) . Signs and symptoms of a blood clot include chest pain, shortness of breath, fast heartbeat, and pain or tenderness in the legs. generic drugs) are not considered. Sorry, we have no data available. These are not all the possible risks associated with DOPTELET. Doptelet is a registered trademark of AkaRx, Inc.Sobi is a trademark of Swedish Orphan Biovitrum AB (publ) 2021 Sobi, Inc. - All rights reserved, PM-US-DOP-0381. Please note that Sobi is not responsible for the content of the website you areabout to visit. easy bruising or bleeding (nosebleeds, bleeding gums), purple or red spots on your skin; cold symptoms such as runny or stuffy nose, sneezing, sore throat; Thrombotic/Thromboembolic Complications [see, Low Baseline Platelet Count Cohort (less than 40 x 10, High Baseline Platelet Count Cohort (40 to less than 50 x 10. Signs of a common cold. Dova Pharmaceuticals (2018): Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The most common adverse reactions (those occurring in 3% of patients) in the DOPTELET-treated groups (60 mg or 40 mg) across the pooled data from the two trials are summarized in Table 5. Avatrombopag (Doptelet) - Side Effects, Interactions, Uses, Dosage Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Doptelet only for the indication prescribed. Side Effects of Doptelet (Avatrombopag Tablets), Warnings, Uses - RxList Side effects that you should report to your doctor or health care professional as soon as possible: Allergic Reactions Like Skin Rash, Itching Or Hives, Swelling Of The Face, Lips, Or Tongue Signs And Symptoms Of A Blood Clot Such As Breathing Problems; Changes In Vision; Chest Pain; Severe, Sudden Headache; Pain, Swelling, Warmth In The Leg; Trouble Speaking; Sudden Numbness Or Weakness Of The Face, Arm Or Leg Doptelet (avatrombopag): Basics, Side Effects & Reviews - GoodRx Ask your doctor or pharmacist for more information. Common side effects of Doptelet include: Fever Stomach pain Nausea Headache Tiredness Swelling of the hands or feet This is not a complete list of Doptelet side effects. This Patient Information has been approved by the U.S. Food and Drug Administration. To make sure this medicine is safe for you, tell your doctor if you have ever had: a bleeding or blood clotting disorder other than thrombocytopenia. *, Those who were not taking Doptelet did not reach 50,000 platelets per microliter, https://sobi-northamerica.com/privacy-policy, Eligible patients may pay as little as $0 for each Doptelet prescription, Have commercial insurance that covers Doptelet, Not be enrolled in any state or federal healthcare program such as Medicare, Medicaid, Medigap, Veterans Affairs (VA), Department of Defense (DOD), or TRICARE, Be a resident in the United States or a US Territory, Approved pharmacies, healthcare professionals, and Doptelet Connect can enroll patients, Patients can enroll themselves as well as their caregivers, Patients pay as little as $0 per prescription. The most common adverse reactions (those occurring in 10% of patients) in the DOPTELET-treated patients across the pooled safety data from the four trials are summarized in Table 6. If you take too much DOPTELET, call your healthcare provider or go to the nearest hospital emergency room right away. Hypersensitivity reactions including pruritus, rash, choking sensation, erythema, pharyngeal edema, pruritus generalized, rash macular, swelling face, and swollen tongue. If you have questions about side effects, call your doctor. Your healthcare provider will tell you how much DOPTELET to take and when to start taking it. Take DOPTELET exactly as your healthcare provider tells you to take it. Long-term heavy alcohol consumption can cause: Low Baseline Platelet Count Cohort (<40x10, High Baseline Platelet Count Cohort (40 to <50x10, Combined Baseline Platelet Count Cohorts (<50x10. Although not all of these side effects may occur, if they do occur they may need medical attention. Use: Treatment of thrombocytopenia in patients with chronic liver disease who are scheduled to undergo a procedure. Do not exceed 40 mg per day. Two DOPTELET-treated patients (0.7%) developed hyponatremia. Version: 2.01. What are the side effects of Avatrombopag (Doptelet)? Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. Doptelet is used to increase your platelet count before you have a medical or dental procedure that increases your risk of bleeding. The following adverse reactions have been reported with Doptelet treatment in adult patients with primary chronic immunological thrombocytopenia : Very common (may affect more than 1 in 10 people) fatigue headache. Medical Editor: John P. Cunha, DO, FACOEP. I understand that I can opt out at any time. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. What is Doptelet used for and how does it work? Doptelet is a type of drug called a thrombopoietin receptor agonist. The majority of patients were female (63%) and median subject age was 50.5 years (ranging from 18-88 years of age). A note about side effect percentages Bruising (40%) Headache (30%) Upper respiratory tract infection (example: sinus infection) (23%) Nose bleed (17%) Bleeding from gums (17%) Small bleeds underneath the skin [petechiae] (15%) Fatigue (15%) Sore throat (13%) Joint pain (11%) High blood pressure (11%) Vomiting (4%) The medicine is for use in patients having an invasive procedure (a medical procedure that involves cutting into or puncturing the skin or inserting instruments into the body). What are the possible side effects of DOPTELET? The recommended dosage of Mulpleta is 3 mg taken orally once daily with or without food for 7 days. The most common side effects of Doptelet when used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) are: headache joint pain tiredness bleeding gums bruising purple or red spots on your skin nosebleed runny nose upper respiratory tract infection These are not all of the possible side effects of Doptelet. When given before a medical procedure in people with chronic liver disease: Doptelet is usually taken once daily for 5 days, beginning 10 to 13 days before your procedure. Doptelet - patient leaflet, side effects, dosage | Patient info The following adverse reactions have been identified during post approval use of DOPTELET. Along with its needed effects, avatrombopag (the active ingredient contained in Doptelet) may cause some unwanted effects. Doptelet comes as a tablet that you take by mouth. Your doctor will measure your platelet levels weekly to determine how long to treat you with avatrombopag. Promacta, prednisone, dexamethasone, triamcinolone, Decadron, Deltasone, Nplate. It is not known if DOPTELET passes into your breast milk. RARE side effects If experienced, these tend to have a Severe expression i low amount of sodium in the blood anemia obstruction of a blood vessel by a blood clot a blood clot in an artery a. Doptelet for Liver Disease: Drug Side Effects & Dosage - MedicineNet No dosage adjustments are required for patients with chronic liver disease. DOPTELET (dop-TEL-et) Avatrombopag Chemotherapy Have a Question ? Tell your healthcare provider right away if you have signs and symptoms of a blood clot, including: The most common side effects of DOPTELET when used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) are: These are not all the possible side effects of DOPTELET. Mulpleta vs Doptelet - What's the difference? - Drugs.com Some side effects may not be reported. Please indicate that you accept the terms and conditions. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. [Ref], Very common (10% or more): Headache (up to 31%)[Ref], Very common (10% or more): Fatigue (up to 28%), pyrexia (up to 11%), Common (1% to 10%): Edema peripheral[Ref], Very common (10% or more): Contusion (26%), Common (1% to 10%): Thromboembolic events, Very common (10% or more): Epistaxis (19%), upper respiratory tract infection (15%), nasopharyngitis (10%), Postmarketing reports: Choking sensation, pharyngeal edema, Very common (10% or more): Arthralgia (13%), Very common (10% or more): Gingival bleeding (13%), Common (1% to 10%): Abdominal pain, nausea[Ref], Very common (10% or more): Petechiae (11%), Postmarketing reports: Pruritus, rash, erythema, pruritus generalized, rash macular, Postmarketing reports: Hypersensitivity reactions, swelling face, swollen tongue. Tell your doctor right away if you have symptoms of a blood clot, including: What is DOPTELET (avatrombopag) [dop-TELL-it]? The most common side effects of Doptelet are: Doptelet is a TPO-RA and TPO-RAs have been associated with blood clots. If you are taking DOPTELET for chronic immune thrombocytopenia and you miss a dose of DOPTELET, take it as soon as you remember. Doptelet for Liver Disease: Drug Side Effects & Dosage - MedicineNet Do not give DOPTELET to other people, even if they have the same symptoms that you have. Doptelet side effects. Doptelet (avatrombopag)." DOPTELET is a prescription medicine used to treat low blood platelet counts in adults with chronic immune thrombocytopenia (ITP) when other treatments have not worked well enough. The most common side effects ( 3%) reported with Doptelet are: fever, stomach pain, nausea, headache, fatigue, and swelling in the hands or feet (edema). The following side effects have been reported to be associated with treatment with Doptelet in adult patients with primary chronic immune thrombocytopenia : Very common (may affect more than 1 in 10 people) feeling tired. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Tell your doctor if you are pregnant or plan to become pregnant before using Doptelet; it may harm a fetus. Follow all directions on your medicine label and package. DOPTELET (avatrombopag) Side Effects & Study Results for ITP Adverse reactions resulting in discontinuation of DOPTELET were anemia, pyrexia, and myalgia; each was reported in a single (0.4%) patient in the DOPTELET (60 mg) treatment group. DOPTELET (dop-TEL-et) Avatrombopag Chemotherapy Have a Question ? pain, swelling, or redness in one or both legs; sudden fever or chills, yellowing of your skin or eyes; or. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. Table 5: Adverse Reactions with a Frequency 3% in Patients with Chronic Liver Disease Treated with DOPTELET - Pooled Data ADAPT-1 and ADAPT-2. DOPTELET may harm your unborn baby. You may report them to the FDA. Doptelet is used to treat thrombocytopenia (a lack of platelets in the blood) in adults with chronic liver disease who are scheduled to undergo a medical procedure. Keep DOPTELET and all medicines out of the reach of children. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Doptelet is usually taken once daily to treat chronic immune thrombocytopenia. Learn more about these and Doptelet interactions with other drugs. Feeling tired or weak. For the High Baseline Platelet Count Cohort, the incidence of serious adverse reactions was 8% (9/115) in the 40 mg DOPTELET treatment group. Mulpleta (lusutrombopag) Mulpleta dosing starts 8 to 14 days prior to the scheduled procedure. We comply with the HONcode standard for trustworthy health information. Your doctor may occasionally change your dose. In patients starting moderate or strong dual inducers of CYP2C9 and CYP3A4 while receiving DOPTELET, monitor platelet counts and adjust DOPTELET dose as necessary (see Table 3) [see DOSAGE AND ADMINISTRATION]. Please contact your doctor or pharmacist. You can ask your pharmacist or healthcare provider for information about DOPTELET that is written for health professionals. These are not all of the side effects that may occur. The study uses data from the FDA. This monograph has been modified to include the generic and brand name in many instances. How do you take Doptelet before a medical or dental procedure. Avatromobopag (Doptelet) is used to treat patients with low platelet count either due to liver disease or immune thrombocytopenia. It is not known if DOPTELET is safe and effective in children. For chronic immune thrombocytopenia: Take the missed dose as soon as you remember it. Take your next dose at your usual scheduled time. Tell your doctor all medications and supplements you use. Common (may affect up to 1 in 10 people) back pain, muscle pain, joint pain, pain in arms or legs. 1. The most common side effects of Doptelet are: Headache Tiredness Bruising Nosebleed Upper respiratory tract infection Joint pain Gum bleeding Purple or red spots on your skin Runny nose Call your doctor for medical advice about side effects. Common side effects may include: fever; easy bruising or bleeding (nosebleeds, bleeding gums), . Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Data sources include IBM Watson Micromedex (updated 1 Nov 2022), Cerner Multum (updated 25 Oct 2022), ASHP (updated 12 Oct 2022) and others. Note: This document contains side effect information about avatrombopag. 12 Medicines That Could Help. It stimulates your bone marrowto make more platelets, which reduces your risk of bleeding. Dosage of drugs is not considered in the study. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Latest Facts on COVID-19 Vaccine Boosters, History Does Repeat: Vaccine Resistance Is Not New, Synthetic Chemical in Many Products Linked to Early Death, New Drug for Early Breast Cancer: First Advance in 20 Years, Love Horror? Tablet coating film: polyvinyl alcohol, talc, polyethylene glycol, titanium dioxide and ferric oxide yellow. Comments: Patients should undergo their procedure 5 to 8 days after the last dose of this drug. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Select a condition to view a list of medication options. Do not use DOPTELET for a condition for which it was not prescribed. Doptelet Patient Information is supplied by Cerner Multum, Inc. and Doptelet Consumer information is supplied by First Databank, Inc., used under license and subject to their respective copyrights. If you take DOPTELET to treat your low blood platelet counts due to chronic immune thrombocytopenia, your healthcare provider will check your platelet count before, during and for at least 4 weeks after stopping your treatment with DOPTELET. Call your doctor for medical advice about side effects. Adverse reactions resulting in discontinuation of DOPTELET that were reported in more than 1 patient included headache, occurring in 1.6% (2/128). Medically reviewed by Philip Thornton, DipPharm. For more information, please see the Sobi Privacy Policy at, Acceptance in this Program is not conditioned on any past, present, or future purchase, including additional doses, Enrollment for the Copay Program is valid through the calendar year, Sobi reserves the right to change program terms at any time, 49 people were in a 6-month clinical trial for Doptelet (clinical trials for a rare disease usually have smaller sample sizes than non-rare disease trials), During that time, people taking Doptelet were compared with people not taking Doptelet, In a 6-month trial, those taking Doptelet were able to keep platelet counts at 50,000 platelets per microliter or higher for an average of 12 total weeks vs 0 weeks for those not taking Doptelet, On Day 8 of the trial, 21 out of 32 people taking Doptelet reached at least 50,000 platelets per microliter or more, Swelling, pain, or tenderness in your legs. Take your next dose at the regular time and stay on your once-daily schedule. Last reviewed on RxList: 10/21/2021 bloody or tarry stools, coughing up blood or vomit that looks like coffee grounds. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Some dosage forms listed on this page may not apply to the brand name Doptelet. Tell your doctor about all your current medicines and any medicine you start or stop using. Use the medicine exactly as directed. DOPTELET is not used to make platelet counts normal in adults with chronic immune thrombocytopenia. This is not a complete list of side effects and others may occur. The pooled safety data from these four clinical trials includes 128 patients who received 2.5 to 40 mg of DOPTELET once daily for a median duration of exposure of 29.1 weeks and had 1 post-dose safety assessment. Doptelet side effects and drug details - Inside Rx Common Doptelet side effects may include: fever; easy bruising or bleeding (nosebleeds, bleeding gums), purple or red spots on your skin; feeling tired; headache, joint pain; cold symptoms such as runny or stuffy nose, sneezing, sore throat; nausea, stomach pain; or swelling in your hands or feet. It's not meant to return your platelet levels. Get medical help right away if any of these side effects occur: shortness of breath/rapid breathing, chest/jaw/left arm pain, unusual sweating, confusion, sudden dizziness/fainting, pain/swelling/warmth in the groin/calf, sudden/severe . Keep each tablet in the foil blister pack until you are ready to take a dose. Doptelet: Uses, Dosage, Side Effects, Warnings - Drugs.com are breastfeeding or plan to breastfeed. DOPTELET is not used to make platelet [] Nose or throat irritation. Reduce the starting dosage of DOPTELET when used concomitantly with a moderate or strong dual inhibitor of CYP2C9 and CYP3A4 (see Table 4) [see DOSAGE AND ADMINISTRATION]. Overview avatrombopag Interaction Characteristics: CYP2C9 substrate CYP3A4 substrate P-gp substrate thrombogenic effects Avoid/Use Alternative efavirenz doptelet Side Effects, Uses, Interactions, Pictures, Warnings - WellRx Doptelet: Dosage, uses, side effects, and more - Medical News Today The most common side effects of Doptelet include: fever, easy bruising, unusual bleeding (nosebleeds, bleeding gums), purple or red spots on your skin, tiredness, headache, joint pain, runny or stuffy nose, sneezing, sore throat, nausea, stomach pain, and swelling in your hands or feet Do not take 2 doses at one time to make up for a missed dose.
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