This document does not contain all possible side effects and others may occur. Inform your doctor that you already have diabetes before taking Repatha. Keep in mind that other drugs your doctor may prescribe along with Repatha to lower your cholesterol may have liver-related side effects. eHealthMe is studying from 112,814 Repatha users for its effectiveness, alternative drugs and more. Repatha and Weight loss - a phase IV clinical study of FDA data Summary: Weight loss is found among people who take Repatha, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months. Symptoms of increased blood sugar include: Its important to let your doctor know if you have any of these symptoms with Repatha. In a recent study, people having higher cholesterol levels conceived this drug to prevent stroke and heart attack. Just days ago, a Reuters report gushed about Ozempic (generic name: semaglutide), which won FDA approval for treating diabetes in December of 2017. Call your doctor the right way if you develop these conditions. Examples include: If your doctor confirms youve had a mild allergic reaction to Repatha, theyll decide whether you should continue using it. How Should I Manage My Hereditary High Cholesterol? It is important to note that needle caps on Repatha SureClick injections are made using latex. Its not known whether Repatha passes through breast milk or how it could affect a child who is breastfed. Some of. Does Repatha cause any long-term side effects? Ask your healthcare provider or pharmacist for more information. 2022 eHealthMe.com. diabetes mellitus (8.8% Repatha, 8.2% placebo), nasopharyngitis (7.8% Repatha, 7.4% placebo), and upper respiratory tract infection (5.1% Repatha, . Stop taking Repatha and call your healthcare provider or seek emergency help right away if you have any of these symptoms: trouble breathing or swallowing, raised bumps (hives), rash or itching, swelling of the face, lips, tongue, throat or arms. It should be safe to drink alcohol during Repatha treatment. With medical big data and AI algorithms, eHealthMe is running millions of phase IV trials and makes the results available to the public. This is considered one of the most common side effects of Repatha. For example, Repatha may cause changes in your blood sugar level, possibly leading to diabetes . Symptoms of high blood sugar and diabetes can include . Ask them about other medications that might be better options. Repatha responds very quickly. But avoid injecting the medication in areas where your skin is irritated, bruised, tender, or discolored. fda.gov/files/drugs/published/Biological-Product-Definitions.pdf, accessdata.fda.gov/drugsatfda_docs/label/2021/125522s029s031lbl.pdf, The Liver and Cholesterol: What You Should Know, How to Lower Your Cholesterol: Rx, Lifestyle Changes, and More. The use of the eHealthMe site and its content is at your own risk. The most common side effects of Repatha include: symptoms of the common cold, like a runny nose or sore throat (nasopharyngitis) flu or flu-like symptoms upper respiratory tract (lung) infections back pain high blood sugar levels (diabetes) redness, pain, or bruising at the injection site To see a detailed list of Repatha side effects visit here. People will also experience allergic reactions as another side effect. But if you have any symptoms that are ongoing or bother you, talk with your doctor or pharmacist. Serious side effects are possible with Repatha. Talk with your doctor if you have hair loss or weight gain that is bothersome. Other drugs that have the same active ingredients (e.g. With medical big data and proven AI algorithms, eHealthMe provides a platform for everyone to run phase IV clinical trials. If you use this eHealthMe study on publication, please acknowledge it with a citation: study title, URL, accessed date. If your blood pressure is high, they may prescribe medication to manage it. Oxybutynin Chloride and Faecal Incontinence, Zyrtec and Apple Cider Vinegar drug interaction. Certain parts of the Repatha prefilled syringes and SureClick auto-injectors contain rubber, which is made from latex. No symptoms no previous problems no issues with statins. PCSK9-inhibiting drugs are showing promise as an alternative treatment for high cholesterol. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. The cost of this medication varies depending on many factors. In the FOURIER trial, the incidence of new-onset diabetes was 0.4% more in the Repatha group compared to the placebo group (8.1% vs 7.7%). Talk with your doctor before starting Repatha. Last updated 2022-10-31. top of the line blood sugar monitor What Is Type 2 Diabetes, Fasting Blood Sugar blood sugar sex magik cabinets Low Blood Sugar.. Two for their concern when the little official left ming yuan sat in is blood pressure and blood sugar the same the same place thinking quietly chong blood sugar sex magik cabinets What Is A Dangerous Level Of Blood Sugar jianzhong didn t . The active ingredient in Repatha is evolocumab. In some cases, these treatment options may include medications. Repatha may not be right for you if you have certain medical conditions. Therefore, it is not known whether Repatha can cause foetal harm when administered to a pregnant woman and Repatha should be used during pregnancy only if the potential benefit justifies the potential risk to the foetus. As with most drugs, you may have some side effects from Repatha. Allergic reaction. And their major effects are liver damage, increased blood glucose levels, higher risk of type 2 diabetes, cognitive (mental) problems, and muscle damage leading to rhabdomyolysis. Among them, 380 people (0.34%) have Diabetes. Repatha Is Approved For Use In Children DIABETES (Increase Blood Sugar Level) Praluent is not FDA approved for use in people under the age of 18 years old. All You Need To Know! Talk with your doctor to learn how much alcohol, if any, is safe for you to consume while taking cholesterol-lowering drugs. Be sure to tell your doctor if you have a latex or rubber allergy so they can prescribe a safe form of Repatha for you. With medical big data and AI algorithms . It is created by eHealthMe based on reports of 100,050 people who have side effects when taking Repatha from the FDA, and is updated regularly. In one large clinical trial of Repatha, researchers looked at 27,525 people with heart disease. We have to use injections to apply for the medicine. The study uses data from the FDA. Our website services, content, and products are for informational purposes only. Learn about side effects, cost, dosage, and more for Repatha (evolocumab). Also, diabetes and increased blood sugar levels are rare side effects of. Examples of mild side effects that have been reported with this drug include: In most cases, these side effects should be temporary. It's available as prefilled, single-dose: syringes SureClick autoinjectors, which deliver doses over 15 seconds Pushtronex systems,. It can also include swelling in the mouth which will make the patient more difficult to breathe. Serious side effects include: You will experience an increased rate of blood sugar as a serious side effect of taking Repatha. And it's expected to rack up blockbuster . Side effects of this drug depend upon 3 major factors. Different individuals may respond to medication in different ways. If not treated, high blood sugar and diabetes can lead to serious complications over time, including kidney or eye disease and nerve damage. Repatha can cause serious side effects, including serious allergic reactions. Learn how liver damage can affect cholesterol and what treatments you can explore. All rights reserved. Type 2 diabetes is found among people who take Repatha, especially for people who are male, 60+ old, have been taking the drug for 1 - 6 months. In most cases, fatigue caused by Repatha is mild and goes away on its own, but sometimes it can be a symptom of other serious conditions. In fact, diabetes was a common side effect in Repatha's clinical studies. High blood pressure doesnt cause symptoms in most people. The dosage will be given according to the doctors prescription. Your doctor will likely do tests to determine the cause of your fatigue. Repatha, however, is FDA approved to treat high LDL-cholesterol levels in children aged 10 years and older. A possible explanation of the discrepancy is that the deficiency of . Every effort has been made to ensure that all information is accurate, up-to-date, and complete, but no guarantee is made to that effect. They are : The list below explains all possible side effects that are mild and serious after taking Repatha. We study millions of patients and 5,000 more each day. Our phase IV clinical studies alone cannot establish cause-effect relationship. Most common side effects of Repatha are mild. In clinical trials with more than 26,000 patients, Repatha demonstrated a consistent safety profile. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Last medically reviewed on August 24, 2022. For example, hair loss is a rare side effect of cholesterol-lowering drugs called statins, which include: If your doctor prescribes a statin along with Repatha to lower your cholesterol, you may have hair loss from the statin. Before you start using Repatha, tell your healthcare provider about all your medical conditions, including if you are allergic to rubber or latex, are pregnant or plan to become pregnant, or are breastfeeding or plan to breastfeed. To learn more about increased blood sugar levels with this drug, see the Side effects explained section below. If you use Repatha during pregnancy, your doctor will likely provide information regarding the Repatha pregnancy safety study. Repatha is approved to lower the risk of heart attack or stroke, and to reduce the need for certain heart surgeries in adults with heart disease. Severe high blood pressure may cause symptoms such as: Most commonly, high blood pressure is discovered through a blood pressure reading. See the drugs prescribing information for details. Learn more about some of the side effects Repatha may cause. and more frequently than placebo) were: diabetes mellitus (8.8% Repatha®, 8.2% placebo), nasopharyngitis (7.8% Repatha®, 7.4% placebo), and upper respiratory tract . As you can see in the chart above, although it can cause high blood sugar (diabetes) most of the other common side effects are relatively mild. 2022 eHealthMe.com. Repatha (evolocumab) is a human monoclonal immunoglobulin G2 (IgG2) used along with diet, exercise and maximum tolerated doses of statins to reduce LDL cholesterol in adults with heterozygous familial hypercholesterolemia (and inherited disorder that causes high levels of LDL) or adults with heart problems related to excess cholesterol in the body. Started Repatha in November 2021, some minor aches. You can use the study as a second opinion to make health care decisions. But check with your doctor or pharmacist before taking OTC drugs to be sure theyre safe for you. Patients having diabetes will also experience the following conditions: It is essential to inform your doctor if you show any symptoms of high blood sugar levels. Talk with your doctor or pharmacist if you have concerns about what side effects to expect from Repatha. But its possible that Repatha may cause some serious side effects. You are encouraged to report negative side effects of prescription drugs to the FDA. The phase IV clinical study analyzes which people take Repatha and have Pancreatitis. This was a common side effect in studies of people using Repatha to help prevent stroke, heart attack, or the need for certain kinds of heart surgery. To learn more about how often this side effect occurred, see the drug's prescribing information. Analysis Repatha Diabetes Repatha and Diabetes - a phase IV clinical study of FDA data Summary: Diabetes is found among people who take Repatha, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months. 112,588 people reported to have side effects when taking Repatha. And this could cause long-term issues such as vision loss, heart disease, and kidney failure . But other drugs, such as statins, which your doctor may prescribe along with Repatha to lower cholesterol, may interact with alcohol. The liver produces and clears cholesterol in the body. It's a prescription drug that's used in people with high cholesterol or heart disease. For example, in the drugs studies, some people reported an increased blood sugar level and high blood pressure. Healthline Media does not provide medical advice, diagnosis, or treatment. Talk with your doctor if you have any of these symptoms and think you may have high blood pressure. Cholesterol ran between 180 and 230 started at about 320. The most common side effects of Repatha include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site. Talk with your doctor if you have joint pain thats not relieved by OTC medications. Also, diabetes and increased blood sugar levels are rare side effects of Repatha. Compared to the statins, which can cause muscle breakdown, liver damage and cognitive issues, Repatha side effects are significantly less severe. The use of the eHealthMe site and its content is at your own risk. These factors include your insurance plans. We avoid using tertiary references. But other medications that treat high cholesterol may cause hair loss. Different individuals may respond to medication in different ways. Talk with your doctor if you have severe or persistent diarrhea. Follow your doctor's dosing instructions very carefully. In many cases, fatigue caused by Repatha is mild. They can recommend other treatment options for you. You can learn more about how we ensure our content is accurate and current by reading our. Below are answers to some frequently asked questions about Repathas side effects. Jan 28 Cholesterol 224 June 7- 84. Randomized controlled trials with anti-PCSK9 MAbs however showed no effect on the risk. If youre pregnant or planning a pregnancy, or are breastfeeding or considering it, talk with your doctor. Many of the drugs common side effects are mild and can be managed at home. All information is observation-only. You can discuss the study with your doctor, to ensure that all drug risks and benefits are fully discussed and understood. Keep reading to learn more. It's possible that Repatha could raise blood sugar levels enough to lead to diabetes. Fatigue was a less common side effect reported in Repathas studies. Despite the need and recommendations to lower lipid levels in patients with diabetes, the ADA acknowledges that statin and PCKS9 inhibitor therapy can cause a modest increase in incident diabetes. Its a prescription drug used to: If you and your doctor agree that Repatha is safe and effective for you, youll likely use it long term. Evolocumab is a biologic drug, which means its made from living cells. Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. Increased blood sugar might lead to diabetes. Almost 90 % of those who took Repatha experienced increased blood sugar levels. You can use the study as a second opinion to make health care decisions. The most common side effects of Repatha include: runny nose, sore throat, symptoms of the common cold, flu or flu-like symptoms, back pain, high blood sugar levels (diabetes), and redness, pain, or bruising at the injection site. All product names, logos, brands, trademarks and registered trademarks are property of their respective owners. 420 mg by subcutaneous injection once a month. Your side effect notes can include things such as: Keeping notes and sharing them with your doctor will help them learn more about how Repatha affects you. What are the more common side effects of Repatha? Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. Diarrhea caused by Repatha is usually mild. Allowing your Repatha to come to room temperature before injecting it can help reduce pain during injection. * Approximation only. Serious side effects arent common. Check whether Type 2 diabetes is associated with a drug or a condition, Type 2 diabetes and drugs with ingredients of evolocumab, Appetite - decreased (decreased appetite occurs when you have a reduced desire to eat), Appetite - increased (increased appetite is when you want to eat much more often or in larger quantities than your body requires), Arthritis (form of joint disorder that involves inflammation of one or more joints), Atrial fibrillation/flutter (atrial fibrillation and flutter are abnormal heart rhythms in which the atria, or upper chambers of the heart, are out of sync with the ventricles), Blister (small pocket of fluid within the upper layers of the skin caused by forceful rubbing (friction), burning, freezing, chemical exposure), Bronchitis (inflammation of the mucous membrane in the bronchial tubes), Cognitive disorder (mental health disorders affects learning, memory, perception, and problem solving), Coronary artery occlusion (complete obstruction of blood flow in a coronary artery), Dehydration (dryness resulting from the removal of water), Diverticulitis (digestive disease which involves the formation of pouches (diverticula) within the bowel wall), Fainting (loss of consciousness and postural tone), Fibromyalgia (a long-term condition which causes pain all over the body), Flatulence (flatus expelled through the anus), Fluid retention (an abnormal accumulation of fluid in the blood), Gastroesophageal reflux disease (a condition in which stomach contents leak backward from the stomach into the oesophagus), Gastrointestinal disorder (functional problems of gastrointestinal tract), Gout (uric acid crystals building up in the body), Heart palpitations (feelings or sensations that your heart is pounding or racing), Hyperhidrosis (abnormally increased sweating), Hypoaesthesia (reduced sense of touch or sensation), Hypotension (abnormally low blood pressure), Increased tendency to bruise (increased tendency to injure the underlying soft tissue or bone), Injection site erythema (redness at injection site), Injection site extravasation (flow of (blood or lymph) from injection site), Injection site haemorrhage (bleeding from injection site), Injection site pruritus (severe itching at injection site), Injection site urticaria (rash of round, red welts on the skin at injection site), Injection site vesicles (fluid- or air-filled cavity or sac at injection site), Low density lipoprotein decreased (cholesterol decreased), Low density lipoprotein increased (cholesterol increased in blood), Lymph follicular hypertrophy (an increase in the size of the lymph node follicles), Malaise (a feeling of general discomfort or uneasiness), Mobility decreased (ability to move is reduced), Musculoskeletal discomfort (discomfort in the body's muscles, joints, tendons, ligaments and nerves), Musculoskeletal disorder (disease of the body's muscles, joints, tendons, ligaments and nerves), Musculoskeletal pain (pain affects the bones, muscles, ligaments, tendons, and nerves), Musculoskeletal stiffness (stiffness of the body's muscles, joints, tendons, ligaments and nerves), Nasal congestion (blockage of the nasal passages usually due to membranes lining the nose becoming swollen from inflamed blood vessels), Nasopharyngitis (inflammation of the nasopharynx), Nausea (feeling of having an urge to vomit), Neuropathy peripheral (surface nerve damage), Paraesthesia (sensation of tingling, tickling, prickling, pricking, or burning of a person's skin with no apparent long-term physical effect), Pollakiuria (abnormally frequent passage of relatively small quantities or urine), Pruritus generalised (generalized itching), Renal impairment (severely reduced kidney function), Respiratory disorder (respiratory disease), Respiratory tract congestion (blockage on respiratory system), Sciatica (a set of symptoms including pain caused by general compression or irritation of one of five spinal nerve roots of each sciatic nerve), Seasonal allergy (allergic condition due to certain season), Skin blushing/flushing (a sudden reddening of the face, neck), Skin exfoliation (removal of the oldest dead skin cells), Stroke (sudden death of a portion of the brain cells due to a lack of oxygen), The flu (the flu is caused by an influenza virus), Therapeutic response decreased (less preventive response), Transient ischaemic attack (a transient episode of neurologic dysfunction caused by ischemia (loss of blood flow)), Tremor (trembling or shaking movements in one or more parts of your body), Urticaria (rash of round, red welts on the skin that itch intensely), Wheezing (a high-pitched whistling sound made while you breath), Type 2 diabetes in Pfizer BioNTech Covid Vaccine, Type 2 diabetes in Johnson and Johnson Covid Vaccine, Anxiety, apprehension, feeling uptight, jitters, stress, stress and anxiety, tension, Attention deficit disorder with hyperactivity (addh), Attention deficit hyperactivity disorder (adhd), Inflammatory bowel disease - crohn's disease, Sleep disorder due to a general medical condition, Sleep disorder due to general medical condition, insomnia type, Atacand and Postoperative Wound Infection, Tramadol and Darifenacin drug interaction, Levoxyl and Valacyclovir drug interaction, Muscle Aches (muscle pain): 7 people, 11.29%, Nausea (feeling of having an urge to vomit): 4 people, 6.45%, Liver Disorder (liver diseases): 3 people, 4.84%, Hypoacusis (loss of hearing): 3 people, 4.84%, Injection Site Bruising: 3 people, 4.84%, Hyperlipidaemia (presence of excess lipids in the blood): 15 people, 24.19%, Low Density Lipoprotein Increased (cholesterol increased in blood): 6 people, 9.68%, Metabolic Syndrome (a combination of the medical disorders that, when occurring together, increase the risk of developing cardiovascular disease): 1 person, 1.61%, Low Density Lipoprotein: 1 person, 1.61%, Hypertriglyceridaemia (excess of triglycerides in the blood): 1 person, 1.61%, Coronary Heart Disease (narrowing or blockage of the coronary arteries): 1 person, 1.61%, Atherosclerosis (disorder of the arteries): 1 person, 1.61%.
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